BDBM474194 3-(6-chloro-2,3-dihydro-1H- inden-1-yl)-7-(4-methoxybenzyl)- 6-methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 74::US10912773, Example 74::US11472810, Example 74

SMILES COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCc3ccc(Cl)cc23)cc1

InChI Key InChIKey=COANVSPOSPBLGF-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 474194   

LigandPNGBDBM474194(3-(6-chloro-2,3-dihydro-1H- inden-1-yl)-7-(4-metho...)
Affinity DataIC50:  5nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474194(3-(6-chloro-2,3-dihydro-1H- inden-1-yl)-7-(4-metho...)
Affinity DataIC50:  2nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474194(3-(6-chloro-2,3-dihydro-1H- inden-1-yl)-7-(4-metho...)
Affinity DataIC50:  3nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474194(3-(6-chloro-2,3-dihydro-1H- inden-1-yl)-7-(4-metho...)
Affinity DataIC50:  5nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474194(3-(6-chloro-2,3-dihydro-1H- inden-1-yl)-7-(4-metho...)
Affinity DataIC50:  2nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474194(3-(6-chloro-2,3-dihydro-1H- inden-1-yl)-7-(4-metho...)
Affinity DataIC50:  3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474194(3-(6-chloro-2,3-dihydro-1H- inden-1-yl)-7-(4-metho...)
Affinity DataIC50:  5nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474194(3-(6-chloro-2,3-dihydro-1H- inden-1-yl)-7-(4-metho...)
Affinity DataIC50:  2nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474194(3-(6-chloro-2,3-dihydro-1H- inden-1-yl)-7-(4-metho...)
Affinity DataIC50:  3nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474194(3-(6-chloro-2,3-dihydro-1H- inden-1-yl)-7-(4-metho...)
Affinity DataIC50:  5nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzym1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474194(3-(6-chloro-2,3-dihydro-1H- inden-1-yl)-7-(4-metho...)
Affinity DataIC50:  2nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474194(3-(6-chloro-2,3-dihydro-1H- inden-1-yl)-7-(4-metho...)
Affinity DataIC50:  3nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent