BDBM475689 6- [(4aS*,8aR*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]pyrimidin-4- yl)- 3,4,4a,5,6,8- hexahydro-1H- 2,7- naphthyridin-2- yl]-5-methyl- pyridine-3- carbonitrile::US10851116, Example 11

SMILES Cc1cc(cnc1N1CC[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12)C#N

InChI Key

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 475689   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM475689(6- [(4aS*,8aR*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Affinity DataEC50:  86nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM475689(6- [(4aS*,8aR*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Affinity DataEC50:  976nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM475689(6- [(4aS*,8aR*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Affinity DataEC50:  85nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM475689(6- [(4aS*,8aR*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Affinity DataEC50:  380nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent