BDBM475690 (4aS*,8aR*)-2- (5-bromo-4- methyl-2- pyridyl)-8a- methyl-7-(7H- pyrrolo[2,3- d]pyrimidin-4- yl)- 3,4,4a,5,6,8- hexahydro-1H- 2,7- naphthyridine::US10851116, Example 12

SMILES Cc1cc(ncc1Br)N1CC[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12

InChI Key

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 475690   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM475690((4aS*,8aR*)-2- (5-bromo-4- methyl-2- pyridyl)-8a- ...)
Affinity DataEC50:  203nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM475690((4aS*,8aR*)-2- (5-bromo-4- methyl-2- pyridyl)-8a- ...)
Affinity DataEC50:  4.27E+3nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM475690((4aS*,8aR*)-2- (5-bromo-4- methyl-2- pyridyl)-8a- ...)
Affinity DataEC50:  60nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM475690((4aS*,8aR*)-2- (5-bromo-4- methyl-2- pyridyl)-8a- ...)
Affinity DataEC50:  937nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent