BDBM475724 1-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,3,4,6,7,7a-hexahydropyrrolo[3,4-c]pyridine-2-carbonyl]cyclopentanecarbonitrile ::US10851116, Example 46

SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C(=O)C1(CCCC1)C#N

InChI Key

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 475724   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM475724(1-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Affinity DataEC50:  97nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM475724(1-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Affinity DataEC50:  1.51E+3nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM475724(1-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Affinity DataEC50:  705nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM475724(1-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Affinity DataEC50:  625nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent