BDBM475759 3-(2,3-Dichlorophenyl)-6-(2,8-diazaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-b]pyrazine::US10851110, Example 122::US11466017, Example 122

SMILES Cc1c(N)nccc1-c1n[nH]c2nc(cnc12)N1CCC2(CCC[C@H]2N)CC1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 475759   

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM475759(3-(2,3-Dichlorophenyl)-6-(2,8-diazaspiro[4.5]decan...)
Affinity DataIC50:  205nMAssay Description:Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM475759(3-(2,3-Dichlorophenyl)-6-(2,8-diazaspiro[4.5]decan...)
Affinity DataIC50:  205nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent