BDBM475880 3-(4-((3-(2,6-dichloro-2′-(trifluoromethoxy)-[1,1′-biphenyl]-4-yl)ureido)methyl)phenyl)propanoic acid::US10851050, Example I-36

SMILES OC(=O)CCc1ccc(CNC(=O)Nc2cc(Cl)c(c(Cl)c2)-c2ccccc2OC(F)(F)F)cc1

InChI Key InChIKey=LLBITRXAUAPUPY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 475880   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM475880(3-(4-((3-(2,6-dichloro-2′-(trifluoromethoxy)...)
Affinity DataIC50:  841nMAssay Description:Inverse agonist activity at human RORgammat assessed as inhibition of N-terminal biotinylated co-activator SRC1 recruitment measured after 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM475880(3-(4-((3-(2,6-dichloro-2′-(trifluoromethoxy)...)
Affinity DataIC50:  2.75E+3nMAssay Description:The inhibitory activity of compounds on RORγ receptor was determined by fluorescence resonance energy transfer (FRET) experiments. The inhibitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent