BDBM476175 US10865384, Compound IM-31::US10865384, Example 1a

SMILES Fc1ccc(cc1)-c1nc([nH]c1-c1ccncc1)-c1c(F)cccc1F

InChI Key InChIKey=TWPJJJZCYVFUOA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 476175   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Agency For Science, Technology And Research

US Patent
LigandPNGBDBM476175(US10865384, Compound IM-31 | US10865384, Example 1...)
Affinity DataIC50:  6.70nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter™ p38 MAP kinase binding assay from ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Agency For Science, Technology And Research

US Patent
LigandPNGBDBM476175(US10865384, Compound IM-31 | US10865384, Example 1...)
Affinity DataIC50:  6.80nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter™ p38 MAP kinase binding assay from ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Agency For Science, Technology And Research

US Patent
LigandPNGBDBM476175(US10865384, Compound IM-31 | US10865384, Example 1...)
Affinity DataIC50:  6.40nMAssay Description:Table 3: Small molecules were tested for their inhibitory activities towards casein kinase 1 delta (CK1δ) and 1 epsilon (CK1ϵ). The in vit...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Agency For Science, Technology And Research

US Patent
LigandPNGBDBM476175(US10865384, Compound IM-31 | US10865384, Example 1...)
Affinity DataIC50:  6.80nMAssay Description:Table 3: Small molecules were tested for their inhibitory activities towards casein kinase 1 delta (CK1δ) and 1 epsilon (CK1ϵ). The in vit...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Agency For Science, Technology And Research

US Patent
LigandPNGBDBM476175(US10865384, Compound IM-31 | US10865384, Example 1...)
Affinity DataIC50:  6.40nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter™ p38 MAP kinase binding assay from ...More data for this Ligand-Target Pair
In DepthDetails US Patent