BDBM476403 4-(aminomethyl)naphthalen-1-yl (3S)- 4-[N-(2-benzyl-2-azaspiro[4.5]dec-8- yl)-3-cyclohexyl-D-alanyl]-3- [(thiophen-2- ylmethyl)carbamoyl]piperazine-1- carboxylate::US10875851, Example 59

SMILES NCc1ccc(OC(=O)N2CCN([C@@H](C2)C(=O)NCc2cccs2)C(=O)[C@@H](CC2CCCCC2)NC2CCC3(CCN(Cc4ccccc4)C3)CC2)c2ccccc12

InChI Key InChIKey=JQUIAODRUQJWEM-YWDPPZBZSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476403   

TargetCoagulation factor XII(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM476403(4-(aminomethyl)naphthalen-1-yl (3S)- 4-[N-(2-benzy...)
Affinity DataIC50:  4.60nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent