BDBM476421 2-chlorophenyl (3S)-4-[N-cyclohexyl- 6-(1,1-dioxidoisothiazolidin-2-yl)-D- norleucyl]-3-[(thiophen-2- ylmethyl)carbamoyl]piperazine-1- carboxylate::US10875851, Example 77

SMILES Clc1ccccc1OC(=O)N1CCN([C@@H](C1)C(=O)NCc1cccs1)C(=O)[C@@H](CCCCN1CCCS1(=O)=O)NC1CCCCC1

InChI Key InChIKey=ODFNHJHVFFTZSL-IZLXSDGUSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476421   

TargetCoagulation factor XII(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM476421(2-chlorophenyl (3S)-4-[N-cyclohexyl- 6-(1,1-dioxid...)
Affinity DataIC50:  4.60nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent