BDBM476629 N-(4-(2-pentylhydrazine-1- carbonyl)benzyl)cinnamamide::US10870618, Compound 3d

SMILES CCCCCNNC(=O)c1ccc(CNC(=O)\C=C\c2ccccc2)cc1

InChI Key InChIKey=BQTCOFJJIMMRQO-NTCAYCPXSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 476629   

TargetHistone deacetylase 1(Homo sapiens (Human))
Musc Foundation For Research Development

US Patent
LigandPNGBDBM476629(N-(4-(2-pentylhydrazine-1- carbonyl)benzyl)cinnama...)
Affinity DataIC50:  47.4nMAssay Description:Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 2(Homo sapiens (Human))
Musc Foundation For Research Development

US Patent
LigandPNGBDBM476629(N-(4-(2-pentylhydrazine-1- carbonyl)benzyl)cinnama...)
Affinity DataIC50:  99.6nMAssay Description:Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 3(Homo sapiens (Human))
Musc Foundation For Research Development

US Patent
LigandPNGBDBM476629(N-(4-(2-pentylhydrazine-1- carbonyl)benzyl)cinnama...)
Affinity DataIC50:  32.5nMAssay Description:Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 2(Homo sapiens (Human))
Musc Foundation For Research Development

US Patent
LigandPNGBDBM476629(N-(4-(2-pentylhydrazine-1- carbonyl)benzyl)cinnama...)
Affinity DataIC50:  100nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC2 expressed in Sf9 cells pre-incubated for 2 hrs before acetylated lysine-aminomethyl couma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Musc Foundation For Research Development

US Patent
LigandPNGBDBM476629(N-(4-(2-pentylhydrazine-1- carbonyl)benzyl)cinnama...)
Affinity DataIC50:  691nMAssay Description:Allosteric inhibition of HDAC3 in HEK293 cell lysates pre-incubated for 2 hrs before acetylated lysine-aminomethyl coumarin-BOC addition and measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Musc Foundation For Research Development

US Patent
LigandPNGBDBM476629(N-(4-(2-pentylhydrazine-1- carbonyl)benzyl)cinnama...)
Affinity DataIC50:  47nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC1 expressed in Sf9 cells pre-incubated for 2 hrs before acetylated lysine-aminomethyl couma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Musc Foundation For Research Development

US Patent
LigandPNGBDBM476629(N-(4-(2-pentylhydrazine-1- carbonyl)benzyl)cinnama...)
Affinity DataIC50:  33nMAssay Description:Allosteric inhibition of C-terminal His-tagged recombinant human HDAC3 expressed in Sf9 cells pre-incubated for 2 hrs before acetylated lysine-aminom...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed