BDBM476661 (S)-6-(3-Chloro-5-(prop-1-yn-1-yl)- 1H-indol-2-yl)-2-imino-3,6-dimethyl- tetrahydropyrimidin-4(1H)-one::US10870635, Example 38

SMILES CC#Cc1ccc2[nH]c(c(Cl)c2c1)[C@]1(C)CC(=O)N(C)C(=N)N1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 476661   

TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476661((S)-6-(3-Chloro-5-(prop-1-yn-1-yl)- 1H-indol-2-yl)...)
Affinity DataIC50:  44nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476661((S)-6-(3-Chloro-5-(prop-1-yn-1-yl)- 1H-indol-2-yl)...)
Affinity DataIC50:  24nMAssay Description:A BACE2 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected compounds by AnaSpec BACE2 fluorescent as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent