BDBM477042 US10882857, Example 1::US11673888, Example 1::[2-[2-Cyclopropyl-6-(oxan-4-ylmethoxy)pyridine-4-carbonyl]-3,4-dihydro-1H-isoquinolin-6-yl]-(1,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)methanone
SMILES O=C(N1CCc2[nH]nnc2C1)c1ccc2CN(CCc2c1)C(=O)c1cc(OCC2CCOCC2)nc(c1)C1CC1
InChI Key InChIKey=JSWDEFSQNLESJE-UHFFFAOYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 477042
Affinity DataIC50: 2nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Hoffmann-La Roche
US Patent
Hoffmann-La Roche
US Patent
Affinity DataIC50: 2nMAssay Description:Assay buffer (50 mM Tris-HCl, 140 mM NaCl, 5 mM KCl, 1 mM CaCl2, 1 mM MgCl2, 0.01% Triton-X-100, pH 8.0;ATX solution: ATX (human His-tagged) stock so...More data for this Ligand-Target Pair