BDBM477597 N-(1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)-4,5,6,7-tetrahydro-2,1-benzoxazole-3-carboxamide::US10889564, Example 27

SMILES O=C(NC1CCCc2c1cnn2-c1ccccc1)c1onc2CCCCc12

InChI Key InChIKey=OBJBHYSTPOEYTF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 477597   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477597(N-(1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)-4,...)
Affinity DataIC50:  95nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477597(N-(1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)-4,...)
Affinity DataIC50:  112nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent