BDBM477620 N-[(4R)-1-(2-fluoro-5-methylphenyl)-4,5,6,7-tetrahydro-1H-indazol-4-yl]-4-(trifluoromethyl)pyridine-2-carboxamide::US10889564, Example 50

SMILES Cc1ccc(F)c(c1)-n1ncc2[C@@H](CCCc12)NC(=O)c1cc(ccn1)C(F)(F)F

InChI Key InChIKey=ADJDTKWSVRYLJU-MRXNPFEDSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 477620   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477620(N-[(4R)-1-(2-fluoro-5-methylphenyl)-4,5,6,7-tetrah...)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477620(N-[(4R)-1-(2-fluoro-5-methylphenyl)-4,5,6,7-tetrah...)
Affinity DataIC50:  119nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent