BDBM477935 (1S,5S,6S)-5-(5-((4-chloropyridin-2-yl)ethynyl)-2-fluorophenyl)-1,5-bis(fluoromethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine::US10889581, Example 138
SMILES NC1=N[C@@](CF)([C@@H]2C[C@]2(CF)S1)c1cc(ccc1F)C#Cc1cc(Cl)ccn1
InChI Key InChIKey=MLJGESCVVGWMSL-MISYRCLQSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 477935
Affinity DataIC50: 1.12E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Affinity DataIC50: 9.03E+5nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair