BDBM478040 US10889592, Compound I-18::US11325917, Compound I-18

SMILES C[C@H](CNC(=O)c1sc2nc(C)cnc2c1N)c1ccc(N2CC3CCC(C2)N3)c(c1)C#N

InChI Key InChIKey=IUDBVIYRVHSGCE-NLNFPOJYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 478040   

TargetUbiquitin carboxyl-terminal hydrolase 28(Homo sapiens)
Valo Early Discovery

US Patent
LigandPNGBDBM478040(US10889592, Compound I-18 | US11325917, Compound I...)
Affinity DataIC50:  6.00E+3nMAssay Description:USP28: Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Cor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 25(Homo sapiens)
Valo Health

US Patent
LigandPNGBDBM478040(US10889592, Compound I-18 | US11325917, Compound I...)
Affinity DataIC50:  6.00E+3nMAssay Description:Ubiquitin-Rhodamine 110 Assay for USP25 Activity: The assay was performed in a final volume of 9 μL in assay buffer containing 20 mM Tris-HCl (p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 28(Homo sapiens)
Valo Early Discovery

US Patent
LigandPNGBDBM478040(US10889592, Compound I-18 | US11325917, Compound I...)
Affinity DataIC50:  6.00E+3nMAssay Description:Ubiquitin-Rhodamine 110 Assay for USP28 Activity: Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 25(Homo sapiens)
Valo Health

US Patent
LigandPNGBDBM478040(US10889592, Compound I-18 | US11325917, Compound I...)
Affinity DataIC50:  6.00E+3nMAssay Description:USP25: The assay was performed in a final volume of 9 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corni...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent