BDBM478360 N-(1-(4-(1-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-1-oxopropan-2- yl)phenyl)piperidin-4-yl)acrylamide::US10894786, Comp. No 21

SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)N1CCC(CC1)NC(=O)C=C

InChI Key

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 478360   

TargetCyclin-dependent kinase 12(Homo sapiens)
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM478360(N-(1-(4-(1-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 13(Homo sapiens (Human))
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM478360(N-(1-(4-(1-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-...)
Affinity DataIC50:  73nMAssay Description:LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 12(Homo sapiens)
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM478360(N-(1-(4-(1-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-...)
Affinity DataIC50:  235nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent