BDBM478980 (R)-N-(4-(3-((5-bromo-4- methoxypyrimidin-2- yl)amino)pyrrolidine-1- carbonyl)phenyl)acrylamide::US10894788, Example 20::US11390618, Example 20

SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Br

InChI Key InChIKey=LDEIHUZYZDZIQM-CQSZACIVSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 478980   

TargetCyclin-dependent kinase 12(Homo sapiens)
Kinnate Biopharma

US Patent
LigandPNGBDBM478980((R)-N-(4-(3-((5-bromo-4- methoxypyrimidin-2- yl)am...)
Affinity DataIC50: <100nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-K/Cyclin-dependent kinase 12(Homo sapiens (Human))
Kinnate Biopharma

US Patent
LigandPNGBDBM478980((R)-N-(4-(3-((5-bromo-4- methoxypyrimidin-2- yl)am...)
Affinity DataIC50: <100nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-K/Cyclin-dependent kinase 12(Homo sapiens (Human))
Kinnate Biopharma

US Patent
LigandPNGBDBM478980((R)-N-(4-(3-((5-bromo-4- methoxypyrimidin-2- yl)am...)
Affinity DataIC50: <100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 12(Homo sapiens)
Kinnate Biopharma

US Patent
LigandPNGBDBM478980((R)-N-(4-(3-((5-bromo-4- methoxypyrimidin-2- yl)am...)
Affinity DataIC50: <100nMAssay Description:For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent