BDBM479521 3-amino-6-(2,6-dimethylpyridin-4-yl)- 5-(4-fluorophenyl)-N-(2- (trifluoromethoxy)benzyl)pyrazine- 2-carboxamide::US10898481, Compound 65::US11571420, Compound 65

SMILES Cc1cc(cc(C)n1)-c1nc(C(=O)NCc2ccccc2OC(F)(F)F)c(N)nc1-c1ccc(F)cc1

InChI Key InChIKey=MVBUSACJHSHWPE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 479521   

TargetAdenosine receptor A2a(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM479521(3-amino-6-(2,6-dimethylpyridin-4-yl)- 5-(4-fluorop...)
Affinity DataIC50:  13nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM479521(3-amino-6-(2,6-dimethylpyridin-4-yl)- 5-(4-fluorop...)
Affinity DataIC50:  4.42E+3nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM479521(3-amino-6-(2,6-dimethylpyridin-4-yl)- 5-(4-fluorop...)
Affinity DataIC50:  30nMAssay Description:Binding affinity and specificalities of the compounds against different subtype of human adenosine receptors (hA1, hA2a, hA2b, and hA3) were characte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM479521(3-amino-6-(2,6-dimethylpyridin-4-yl)- 5-(4-fluorop...)
Affinity DataIC50:  13nMAssay Description:Binding affinity and specificalities of the compounds against different subtype of human adenosine receptors (hA1, hA2a, hA2b, and hA3) were characte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM479521(3-amino-6-(2,6-dimethylpyridin-4-yl)- 5-(4-fluorop...)
Affinity DataIC50:  4.42E+3nMAssay Description:Binding affinity and specificalities of the compounds against different subtype of human adenosine receptors (hA1, hA2a, hA2b, and hA3) were characte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM479521(3-amino-6-(2,6-dimethylpyridin-4-yl)- 5-(4-fluorop...)
Affinity DataIC50:  30nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent