BDBM479981 4-(1-Cyclobutyl-3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-2-(4-(methylsulfonyl)phenyl)pyridine::US10899741, Example 1

SMILES Cc1cccc(n1)-c1nn(cc1-c1ccnc(c1)-c1ccc(cc1)S(C)(=O)=O)C1CCC1

InChI Key InChIKey=PWZFPJWFVDRWAK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 479981   

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM479981(4-(1-Cyclobutyl-3-(6-methylpyridin-2-yl)-1H-pyrazo...)
Affinity DataIC50:  208nMAssay Description:TGFβRI kinase assay kit (V4093, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM479981(4-(1-Cyclobutyl-3-(6-methylpyridin-2-yl)-1H-pyrazo...)
Affinity DataIC50:  1.20E+3nMAssay Description:RIPK2 kinase assay kit (V4084, Promega) was used to assay enzyme activity. 2 μl of RIPK2 enzyme solution (the final concentration of enzyme in t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM479981(4-(1-Cyclobutyl-3-(6-methylpyridin-2-yl)-1H-pyrazo...)
Affinity DataIC50:  2.20E+3nMAssay Description:p38α kinase assay kit (V9591, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM479981(4-(1-Cyclobutyl-3-(6-methylpyridin-2-yl)-1H-pyrazo...)
Affinity DataIC50:  2.50E+3nMAssay Description:VEGFR2: Z'-LYTECŪ Kinase Assay Kit—Tyrosine 1 Peptide (PV3190, Invitrogen) was used to assay enzyme activity. 5 μl of recombinant human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent