BDBM480003 (R)-4-(3-(6-Methylpyridin-2-yl)-1-(1-(methylsulfonyl)pyrrolidin-3-yl)-1H-pyrazol-4-yl)-2-(4-(methylsulfonyl)phenyl)pyridine 8::US10899741, Example 8

SMILES Cc1cccc(n1)-c1nn(cc1-c1ccnc(c1)-c1ccc(cc1)S(C)(=O)=O)[C@@H]1CCN(C1)S(C)(=O)=O

InChI Key InChIKey=FIPIGPHWHYHQEG-OAQYLSRUSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 480003   

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM480003((R)-4-(3-(6-Methylpyridin-2-yl)-1-(1-(methylsulfon...)
Affinity DataIC50:  370nMAssay Description:TGFβRI kinase assay kit (V4093, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent