BDBM481772 (R)-3-(2-(4-chlorophenyl)- 2-fluoroethyl)-5-((7-methyl- 6-oxo-6H-purin-1(7H)- yl)methyl)-1,3,4-oxadiazol- 2(3H)-one::US10913742, Example 14

SMILES Cn1cnc2ncn(Cc3nn(C[C@H](F)c4ccc(Cl)cc4)c(=O)o3)c(=O)c12

InChI Key InChIKey=RSSHXKVUURRAKX-LBPRGKRZSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 481772   

TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM481772((R)-3-(2-(4-chlorophenyl)- 2-fluoroethyl)-5-((7-me...)
Affinity DataIC50:  34nMAssay Description:The IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells express...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM481772((R)-3-(2-(4-chlorophenyl)- 2-fluoroethyl)-5-((7-me...)
Affinity DataIC50:  18nMAssay Description:Antagonist activity at rat TRPA1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM481772((R)-3-(2-(4-chlorophenyl)- 2-fluoroethyl)-5-((7-me...)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at human TRPA1 expressed in CHO cells measured by calcium based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed