BDBM482163 N-[3-(4-Amino-7-(1-methyl-piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-2-fluoro-phenyl)-5-chloro-2-fluoro-4-methoxy-benzenesulfonamide::US10918642, Cmpd # 3::US11491158, Cmpd 3

SMILES COc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cccc(-c2cn(C3CCN(C)CC3)c3ncnc(N)c23)c1F

InChI Key InChIKey=WWZFDHRCDWFSMO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 482163   

TargetEukaryotic translation initiation factor 2-alpha kinase 3 [540-1115](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM482163(N-[3-(4-Amino-7-(1-methyl-piperidin-4-yl)-7H-pyrro...)
Affinity DataIC50: <16nMAssay Description:The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM482163(N-[3-(4-Amino-7-(1-methyl-piperidin-4-yl)-7H-pyrro...)
Affinity DataIC50: <16nMAssay Description:Compounds were 3-fold serially diluted in order to obtain from 3.333 to 0.000169 microM final concentration, then incubated for 60 minutes at room te...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent