BDBM483540 2-((4-(N-((S)-4- fluorobicyclo[4.2.0]octa-1(6),2,4-trien- 7-yl)-N''-hydroxycarbamimidoyl)-1,2,5- oxadiazol-3-yl)amino)-N-(2-(S- methylsulfonimidoyl)ethyl)acetamide::US10927086, Example 12::US10927086, Example 13::US10927086, Example 14

SMILES CS(=N)(=O)CCNC(=O)CNc1nonc1\C(N[C@H]1Cc2ccc(F)cc12)=N\O

InChI Key InChIKey=ZXXGYLHFNJASBJ-ZINHSSCWSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 483540   

TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM483540(2-((4-(N-((S)-4- fluorobicyclo[4.2.0]octa-1(6),2,4...)
Affinity DataIC50:  49.3nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM483540(2-((4-(N-((S)-4- fluorobicyclo[4.2.0]octa-1(6),2,4...)
Affinity DataIC50:  63.8nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM483540(2-((4-(N-((S)-4- fluorobicyclo[4.2.0]octa-1(6),2,4...)
Affinity DataIC50:  58.2nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent