BDBM484217 (S)-1-(2-(1-(4-(3- methoxyphenoxy)phenyl)imidazo[1,5- a]pyrazin-3-yl)pyrrolidin-1-yl)prop-2- en-1-one::US10933063, Compound 16::US11554118, Compound 16

SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3ccncc23)c1

InChI Key InChIKey=PGVGTJDOYNQGLQ-QFIPXVFZSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 484217   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484217((S)-1-(2-(1-(4-(3- methoxyphenoxy)phenyl)imidazo[1...)
Affinity DataIC50:  30nMAssay Description:Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484217((S)-1-(2-(1-(4-(3- methoxyphenoxy)phenyl)imidazo[1...)
Affinity DataIC50: <10nMAssay Description:Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484217((S)-1-(2-(1-(4-(3- methoxyphenoxy)phenyl)imidazo[1...)
Affinity DataIC50:  550nMAssay Description:Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484217((S)-1-(2-(1-(4-(3- methoxyphenoxy)phenyl)imidazo[1...)
Affinity DataIC50: >1.00E+5nMAssay Description:Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484217((S)-1-(2-(1-(4-(3- methoxyphenoxy)phenyl)imidazo[1...)
Affinity DataIC50: >1.00E+5nMAssay Description:Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484217((S)-1-(2-(1-(4-(3- methoxyphenoxy)phenyl)imidazo[1...)
Affinity DataIC50:  5.50E+3nMAssay Description:Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484217((S)-1-(2-(1-(4-(3- methoxyphenoxy)phenyl)imidazo[1...)
Affinity DataIC50:  5.50E+3nMAssay Description:The following Table shows the activity of selected compounds of this invention in the BTK, TEC, BLK, LYN, LCK inhibition assay. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticleUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484217((S)-1-(2-(1-(4-(3- methoxyphenoxy)phenyl)imidazo[1...)
Affinity DataIC50: <10nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticleUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484217((S)-1-(2-(1-(4-(3- methoxyphenoxy)phenyl)imidazo[1...)
Affinity DataIC50: <10nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticleUS Patent
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484217((S)-1-(2-(1-(4-(3- methoxyphenoxy)phenyl)imidazo[1...)
Affinity DataIC50:  550nMAssay Description:The following Table shows the activity of selected compounds of this invention in the BTK, TEC, BLK, LYN, LCK inhibition assay. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticleUS Patent
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484217((S)-1-(2-(1-(4-(3- methoxyphenoxy)phenyl)imidazo[1...)
Affinity DataIC50: >1.00E+4nMAssay Description:The following Table shows the activity of selected compounds of this invention in the BTK, TEC, BLK, LYN, LCK inhibition assay. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticleUS Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484217((S)-1-(2-(1-(4-(3- methoxyphenoxy)phenyl)imidazo[1...)
Affinity DataIC50: >1.00E+4nMAssay Description:The following Table shows the activity of selected compounds of this invention in the BTK, TEC, BLK, LYN, LCK inhibition assay. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticleUS Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484217((S)-1-(2-(1-(4-(3- methoxyphenoxy)phenyl)imidazo[1...)
Affinity DataIC50:  5.50E+3nMAssay Description:The following Table shows the activity of selected compounds of this invention in the BTK, TEC, BLK, LYN, LCK inhibition assay. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticleUS Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484217((S)-1-(2-(1-(4-(3- methoxyphenoxy)phenyl)imidazo[1...)
Affinity DataIC50:  5.50E+3nMAssay Description:Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent