BDBM484579 US10934294, Example 100::US10934294, Example 101::US10934294, Example 98::US10934294, Example 99::US11028092, Example 101

SMILES C[C@@H](c1ccc(F)cn1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1

InChI Key

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 484579   

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM484579(US10934294, Example 100 | US10934294, Example 101 ...)
Affinity DataKi:  1.70nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM484579(US10934294, Example 100 | US10934294, Example 101 ...)
Affinity DataKi:  1.70nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM484579(US10934294, Example 100 | US10934294, Example 101 ...)
Affinity DataKi:  16nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM484579(US10934294, Example 100 | US10934294, Example 101 ...)
Affinity DataKi:  16nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM484579(US10934294, Example 100 | US10934294, Example 101 ...)
Affinity DataKi:  321nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM484579(US10934294, Example 100 | US10934294, Example 101 ...)
Affinity DataKi:  321nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM484579(US10934294, Example 100 | US10934294, Example 101 ...)
Affinity DataKi:  392nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM484579(US10934294, Example 100 | US10934294, Example 101 ...)
Affinity DataKi:  392nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent