BDBM486390 N-(1,1- dioxidotetrahydrothiophen-3- yl)-1-(4-fluorophenyl)-3- (pyridin-2-yl)-1H-indole-6- carboxamide (racemic)::US10947222, Example 22

SMILES Fc1ccc(cc1)-n1cc(-c2ccccn2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1

InChI Key InChIKey=AVQYNMAWNVVRDI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 486390   

TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM486390(N-(1,1- dioxidotetrahydrothiophen-3- yl)-1-(4-fluo...)
Affinity DataIC50:  664nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent