BDBM486393 3-(5-(difluoromethoxy)pyridin- 3-yl)-1-(4-fluorophenyl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen-3- yl)-1H-indole-6-carboxamide (racemic)::US10947222, Example 25

SMILES CC1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cc3)c2c1)-c1cncc(OC(F)F)c1

InChI Key InChIKey=HCDCBHVRRBJJGG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 486393   

TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM486393(3-(5-(difluoromethoxy)pyridin- 3-yl)-1-(4-fluoroph...)
Affinity DataIC50:  0.770nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent