BDBM486479 7-chloro-4-ethyl-2-(2-hydroxy-2-((S)-1,2,3,4-tetrahydroisoquinolin-3-yl)ethyl)-3,4-dihydro-2,6-naphthyridin-1(2H)-one Isomer 2::US10947234, Example 2

SMILES CC[C@@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2cc(Cl)ncc12

InChI Key InChIKey=UXPBCMYMGIMOFE-ZNZDAUKMSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 486479   

TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM486479(7-chloro-4-ethyl-2-(2-hydroxy-2-((S)-1,2,3,4-tetra...)
Affinity DataIC50:  3.84E+3nMAssay Description:PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM486479(7-chloro-4-ethyl-2-(2-hydroxy-2-((S)-1,2,3,4-tetra...)
Affinity DataEC50:  1.00E+4nMAssay Description:The PRMT5 TE assay is a biomarker assay for identifying compounds that inhibit symmetric dimethylation of arginine (SDMA) of PRMT5 substrates. This a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM486479(7-chloro-4-ethyl-2-(2-hydroxy-2-((S)-1,2,3,4-tetra...)
Affinity DataIC50:  1.00E+5nMAssay Description:PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent