BDBM486488 7-((1-acetylpiperidin-4-yl)amino)-2-(2-hydroxy-2-((S)-1,2,3,4-tetrahydroisoquinolin-3-yl)ethyl)-4,4-dimethyl-3,4-dihydro-2,6-naphthyridin-1(2H)-one Isomer 1::US10947234, Example 11
SMILES CC(=O)N1CCC(CC1)Nc1cc2C(=O)N(C[C@@H](O)[C@@H]3Cc4ccccc4CN3)CC(C)(C)c2cn1
InChI Key InChIKey=XYWYBTMWNJNVPU-LOSJGSFVSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 486488
Affinity DataIC50: 56.9nMAssay Description:PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...More data for this Ligand-Target Pair
Affinity DataEC50: 3.90E+3nMAssay Description:The PRMT5 TE assay is a biomarker assay for identifying compounds that inhibit symmetric dimethylation of arginine (SDMA) of PRMT5 substrates. This a...More data for this Ligand-Target Pair
Affinity DataIC50: 9.23E+3nMAssay Description:PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...More data for this Ligand-Target Pair