BDBM486544 22::US10947251, Example 21

SMILES COc1nc(c(F)cc1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F

InChI Key InChIKey=QQSSFYLKUHLBGQ-SJLPKXTDSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 486544   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM486544(22 | US10947251, Example 21)
Affinity DataIC50:  47.5nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM486544(22 | US10947251, Example 21)
Affinity DataIC50:  2.00E+3nMAssay Description:Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent