BDBM486547 US10947251, Example 24

SMILES Fc1cc(N2[C@H]3CCN(C[C@@H]3OCC2=O)S(=O)(=O)Nc2ccon2)c(cc1-c1cccc(c1)C(F)(F)F)C#N

InChI Key InChIKey=BMPKQQGNTVQMHQ-FPOVZHCZSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 486547   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM486547(US10947251, Example 24)
Affinity DataIC50:  237nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM486547(US10947251, Example 24)
Affinity DataIC50:  2.00E+3nMAssay Description:Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent