BDBM488456 2-[4-Amino-1-(oxan-4-ylmethyl)-1H-pyrazolo[3,4- d]pyrimidin-3-yl]-3-chloro-N-cyclopropyl-1H- indole-6-carboxamide::US10954241, Example 96::US11548896, Example 96

SMILES Nc1ncnc2n(CC3CCOCC3)nc(-c3[nH]c4cc(ccc4c3Cl)C(=O)NC3CC3)c12

InChI Key InChIKey=DXEHPDDGAHBBGP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 488456   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488456(2-[4-Amino-1-(oxan-4-ylmethyl)-1H-pyrazolo[3,4- d]...)
Affinity DataIC50:  13nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488456(2-[4-Amino-1-(oxan-4-ylmethyl)-1H-pyrazolo[3,4- d]...)
Affinity DataIC50:  1.08E+3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488456(2-[4-Amino-1-(oxan-4-ylmethyl)-1H-pyrazolo[3,4- d]...)
Affinity DataIC50:  20.7nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488456(2-[4-Amino-1-(oxan-4-ylmethyl)-1H-pyrazolo[3,4- d]...)
Affinity DataIC50:  13nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488456(2-[4-Amino-1-(oxan-4-ylmethyl)-1H-pyrazolo[3,4- d]...)
Affinity DataIC50:  1.08E+3nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488456(2-[4-Amino-1-(oxan-4-ylmethyl)-1H-pyrazolo[3,4- d]...)
Affinity DataIC50:  20.7nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent