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BDBM50000334 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-2-one::6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-2-one(BL-4162A)::6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-2-one(anagrelide)::ANAGRELIDE::Agrylin::CHEMBL760

SMILES: Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl

InChI Key: InChIKey=OTBXOEAOVRKTNQ-UHFFFAOYSA-N

Data: 8 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50000334   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM50000334
PNG
(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)
Show SMILES Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl
Show InChI InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)
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n/an/a 3.40E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000334
PNG
(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)
Show SMILES Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl
Show InChI InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)
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n/an/an/an/a 1.05E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM50000334
PNG
(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)
Show SMILES Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl
Show InChI InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)
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n/an/a 3.40E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000334
PNG
(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)
Show SMILES Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl
Show InChI InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)
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n/an/a 82n/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Inhibition of human blood platelet c-AMP phosphodiesterase


J Med Chem 35: 620-8 (1992)


Article DOI: 10.1021/jm00082a002
BindingDB Entry DOI: 10.7270/Q2PZ57SK
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000334
PNG
(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)
Show SMILES Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl
Show InChI InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)
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n/an/a 1.05E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
BindingDB Entry DOI: 10.7270/Q2PN97WB
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000334
PNG
(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)
Show SMILES Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl
Show InChI InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)
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n/an/a 80n/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Inhibition of platelet cAMP phosphodiesterase


J Med Chem 31: 2136-45 (1988)


Article DOI: 10.1021/jm00119a014
BindingDB Entry DOI: 10.7270/Q2VX0JQQ
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000334
PNG
(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)
Show SMILES Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl
Show InChI InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)
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n/an/a 50n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000334
PNG
(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)
Show SMILES Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl
Show InChI InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)
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n/an/an/an/a 1.10n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000334
PNG
(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)
Show SMILES Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl
Show InChI InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)
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n/an/a 54n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000334
PNG
(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)
Show SMILES Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl
Show InChI InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)
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n/an/a 80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperone


J Med Chem 30: 295-303 (1987)


Article DOI: 10.1021/jm00385a011
BindingDB Entry DOI: 10.7270/Q2C24ZNB
More data for this
Ligand-Target Pair