BDBM50000868 CHEMBL88444::{Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyryl]-amino}-acetic acid ethyl ester

SMILES CCOC(=O)CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1

InChI Key InChIKey=KGPRGRZUQMYFDW-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50000868   

TargetP2Y purinoceptor 12(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000868(CHEMBL88444 | {Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H...)
Affinity DataEC50:  20nMAssay Description:Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000868(CHEMBL88444 | {Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000868(CHEMBL88444 | {Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H...)
Affinity DataEC50:  20nMAssay Description:Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000868(CHEMBL88444 | {Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed