BDBM50003624 (RS)-nipecotic acid::CHEMBL277498::Nipecotic::Piperidine-3-carboxylic acid::Piperidine-3-carboxylic acid (6)::Piperidine-3-carboxylic acid(nipecotic acid)
SMILES OC(=O)C1CCCNC1
InChI Key InChIKey=XJLSEXAGTJCILF-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 23 hits for monomerid = 50003624
Affinity DataKi: 110nM ΔG°: -9.49kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...More data for this Ligand-Target Pair
Affinity DataKi: 4.89E+3nM ΔG°: -7.24kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...More data for this Ligand-Target Pair
Affinity DataKi: 5.27E+3nM ΔG°: -7.20kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid type B receptor subunit 1(Rattus norvegicus (Rat))
TBA
Curated by PDSP Ki Database
TBA
Curated by PDSP Ki Database
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Affinity DataKi: 5.82E+4nMAssay Description:Displacement of NO 711 from mouse GAT1 expressed in HEK293 cell membranes after 40 mins by LC-ESI-MS-MS-based MS binding assayMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 2(Mus musculus)
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Affinity DataIC50: 7.96E+5nMAssay Description:Inhibition of mouse GAT2 expressed in HEK293 cells assessed as [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA/unlabeled GABA addition ...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Homo sapiens (Human))
Ludwig-Maximilians-University M£Nchen
Curated by ChEMBL
Ludwig-Maximilians-University M£Nchen
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human GAT1 expressed in COS cells assessed as decrease in [3H]GABA uptake after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 3(Mus musculus)
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Affinity DataIC50: 1.98E+4nMAssay Description:Inhibition of mouse GAT4 expressed in HEK293 cells assessed as [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA/unlabeled GABA addition ...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 3(Homo sapiens (Human))
Zentrum F£R Pharmaforschung
Curated by ChEMBL
Zentrum F£R Pharmaforschung
Curated by ChEMBL
Affinity DataIC50: 1.10E+5nMAssay Description:Binding affinity to GAT3More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 2(Homo sapiens (Human))
Zentrum F£R Pharmaforschung
Curated by ChEMBL
Zentrum F£R Pharmaforschung
Curated by ChEMBL
Affinity DataIC50: 6.60E+4nMAssay Description:Binding affinity to GAT2More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich
Curated by ChEMBL
Ludwig Maximilians University At Munich
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Displacement of [3H]-baclofen from Gamma-aminobutyric acid type B receptor in rat brain membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of high affinity neuronal GABA uptake by synaptosomes of rat brain membraneMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 2(Mus musculus)
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Affinity DataIC50: 5.25E+5nMAssay Description:Inhibition of mouse GAT2 expressed in HEK cells assessed as inhibition of [3H]-GABA uptake after 25 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 3(Mus musculus)
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Affinity DataIC50: 1.95E+4nMAssay Description:Inhibition of mouse GAT3 expressed in HEK cells assessed as inhibition of [3H]-GABA uptake after 25 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Affinity DataIC50: 8.51E+3nMAssay Description:Inhibition of mouse GAT1 expressed in HEK cells assessed as inhibition of [3H]-GABA uptake after 25 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Affinity DataIC50: 1.33E+4nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cells assessed as [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA/unlabeled GABA addition ...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent betaine transporter(Homo sapiens (Human))
Synaptic Pharmaceutical
Curated by ChEMBL
Synaptic Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 2.37E+6nMAssay Description:Inhibition of human GABA transporter (hBGT-1) activity.More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 3(Homo sapiens (Human))
Zentrum F£R Pharmaforschung
Curated by ChEMBL
Zentrum F£R Pharmaforschung
Curated by ChEMBL
Affinity DataIC50: 1.06E+5nMAssay Description:Inhibitory activity against human sodium and chloride dependent GABA transporter 3More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Homo sapiens (Human))
Ludwig-Maximilians-University M£Nchen
Curated by ChEMBL
Ludwig-Maximilians-University M£Nchen
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 2(Rattus norvegicus)
Synaptic Pharmaceutical
Curated by ChEMBL
Synaptic Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 3.90E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 3(Mus musculus)
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of mouse GAT3 expressed in HEK293 cells assessed as [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA/unlabeled GABA addition ...More data for this Ligand-Target Pair