BDBM50004441 (2R,4R)-ketoconazole::1-acetyl-4-(4-{[(2R,4R)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine::CHEMBL328863

SMILES CC(=O)N1CCN(CC1)c1ccc(OC[C@@H]2CO[C@@](Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1

InChI Key InChIKey=XMAYWYJOQHXEEK-BVAGGSTKSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50004441   

TargetLanosterol 14-alpha demethylase(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004441((2R,4R)-ketoconazole | 1-acetyl-4-(4-{[(2R,4R)-2-(...)
Affinity DataIC50:  1.37E+3nMAssay Description:Inhibition of lanosterol 14 alpha-demethylase cytochrome P450 51AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004441((2R,4R)-ketoconazole | 1-acetyl-4-(4-{[(2R,4R)-2-(...)
Affinity DataIC50:  3.83E+4nMAssay Description:Inhibition of cytochrome P450 19A1 involved in steroid biosynthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004441((2R,4R)-ketoconazole | 1-acetyl-4-(4-{[(2R,4R)-2-(...)
Affinity DataIC50:  897nMAssay Description:Inhibition of progesterone 6-beta-hydroxylase in rat hepatic microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A2(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004441((2R,4R)-ketoconazole | 1-acetyl-4-(4-{[(2R,4R)-2-(...)
Affinity DataIC50:  728nMAssay Description:Inhibition of cytochrome P450 progesterone 15-alpha hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 21-hydroxylase(Homo sapiens (Human))
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004441((2R,4R)-ketoconazole | 1-acetyl-4-(4-{[(2R,4R)-2-(...)
Affinity DataIC50:  6.57E+3nMAssay Description:Inhibition of Progesterone 21-hydroxylase cytochrome P450 21More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Bos taurus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004441((2R,4R)-ketoconazole | 1-acetyl-4-(4-{[(2R,4R)-2-(...)
Affinity DataIC50:  135nMAssay Description:Inhibition of Corticoid 11-beta-hydroxylase cytochrome P450More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C11(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004441((2R,4R)-ketoconazole | 1-acetyl-4-(4-{[(2R,4R)-2-(...)
Affinity DataIC50:  2.04E+4nMAssay Description:Inhibition of cytochrome P450 progesterone 2-alpha-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesterol side-chain cleavage enzyme, mitochondrial(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004441((2R,4R)-ketoconazole | 1-acetyl-4-(4-{[(2R,4R)-2-(...)
Affinity DataIC50:  3.92E+3nMAssay Description:Inhibition of cholesterol side chain cleavage cytochrome P450More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 7A1(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004441((2R,4R)-ketoconazole | 1-acetyl-4-(4-{[(2R,4R)-2-(...)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of cytochrome P450 Cholesterol 7-alpha-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed