BDBM50012278 (2ALPHA,2''BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE::CHEMBL159::VINBLASTINE::VINBLASTINE SULFATE::cid_5388983
SMILES CC[C@]1(O)C[C@@H]2CN(C1)CCc1c([nH]c3ccccc13)[C@@](C2)(C(=O)OC)c1cc2c(cc1OC)N(C)[C@@H]1[C@]22CCN3CC=C[C@](CC)([C@@H]23)[C@@H](OC(C)=O)[C@]1(O)C(=O)OC
InChI Key InChIKey=JXLYSJRDGCGARV-CFWMRBGOSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 49 hits for monomerid = 50012278
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by ChEMBL
Bulgarian Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 100nMAssay Description:High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity modelMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by ChEMBL
Bulgarian Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 1.30E+3nMAssay Description:Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affini...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by ChEMBL
Bulgarian Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 2.10E+3nMAssay Description:TP_TRANSPORTER: inhibition of ATPase activity (Verapamil) in membranes from CEM/VLB100 cellsMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
Universit£Tsmedizin G£Ttingen
Curated by ChEMBL
Universit£Tsmedizin G£Ttingen
Curated by ChEMBL
Affinity DataKi: 1.02E+4nMAssay Description:Inhibition of human OATP1B1-mediated [3H]estrone 3-sulfate at after 5 mins by Dixon plot methodMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by ChEMBL
Bulgarian Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 1.50E+4nMAssay Description:TP_TRANSPORTER: transepithelial transport of digoxin (basal to apical) in Caco-2 cellsMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1B3(Homo sapiens (Human))
Universit£Tsmedizin G£Ttingen
Curated by ChEMBL
Universit£Tsmedizin G£Ttingen
Curated by ChEMBL
Affinity DataKi: 1.86E+4nMAssay Description:Inhibition of human OATP1B3-mediated [3H]CCK-8 after 5 mins by Dixon plot methodMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by ChEMBL
Bulgarian Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 3.65E+4nMAssay Description:TP_TRANSPORTER: inhibition of Taxol transepithelial transport (basal to apical) in Caco-2 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 7.70E+4nMAssay Description:Inhibition of bovine liver MAOBMore data for this Ligand-Target Pair
Affinity DataKi: 7.70E+4nMAssay Description:Inhibitory activity of the compound against Monoamine oxidase B isolated from beef liver mitochondria was determinedMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Binding constant at colchicine site of bovine brain tubulinMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by ChEMBL
Bulgarian Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 1.40E+5nMAssay Description:TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) in MDR1-expressing MDCK cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of human cytochrome P450 3A4More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Concentration of compound required to inhibit tubulin polymerization (Microtubule assembly) was determined by the turbidity formation after 20 min of...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by ChEMBL
Bulgarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of P-glycoprotein expressed in A2780/ADR cells by calcein AM assayMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by ChEMBL
Bulgarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of P-glycoprotein by Hoechst assayMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by ChEMBL
Bulgarian Academy Of Sciences
Curated by ChEMBL
Affinity DataKd: 3.00E+3nMAssay Description:TP_TRANSPORTER: binding in membrane vesicle from CEM/VLB100 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by ChEMBL
Bulgarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 2.90E+4nMAssay Description:TP_TRANSPORTER: inhibition of calcein-AM efflux in MDR1-expressing MDCK cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+4nMAssay Description:TP_TRANSPORTER: inhibition of calcein-AM efflux in MRP2-expressing MDCK cellsMore data for this Ligand-Target Pair
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Queen'S University
Curated by ChEMBL
Queen'S University
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.05 uM) in membrane vesicle from MRP1-expressing HeLa cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by ChEMBL
Bulgarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 2.95E+4nMAssay Description:TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by ChEMBL
Bulgarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.77E+4nMAssay Description:TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by ChEMBL
Bulgarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.99E+4nMAssay Description:TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataIC50: 1.15E+5nMAssay Description:TP_TRANSPORTER: increase in bodipy intracellular accumulation (Bodipy: 0.2 uM) in SK-E2 cells (expressing BSEP)More data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataIC50: 6.20E+4nMAssay Description:TP_TRANSPORTER: increase in dihydrofluorescein intracellular accumulation (dihydrofluorescein: 1 uM) in SK-E2 cells (expressing BSEP)More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by ChEMBL
Bulgarian Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 1.46E+4nMAssay Description:TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation (Calcein-AM: 0.25 uM) in MDR-P388 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by ChEMBL
Bulgarian Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 3.40E+4nMAssay Description:TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation (Calcein-AM: 0.25 uM) in MDR-CEM cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by ChEMBL
Bulgarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:In vitro inhibition of maximum porcine tubulin assembly rate after 20 min at 37 degrees CMore data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibition of tubulin polymerization using isolated calf brainMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of tubulin polymerization in porcine brainMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization by microtubule assembly assayMore data for this Ligand-Target Pair
Affinity DataIC50: >2.46E+5nMAssay Description:Inhibition of HIV1 RTMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of pig brain tubulin polymerization after 30 mins by turbidimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of pig brain tubulin polymerization after 30 mins by turbidimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of pig tubulin polymerization determined after 45 mins at 37 degC by turbidimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of porcine brain tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by ChEMBL
Bulgarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by ChEMBL
Bulgarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCECMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by ChEMBL
Bulgarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 3.40E+4nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization assessed as microtubule assembly after 15 mins by DAPI stainingMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of bovine tubulin polymerization by turbidity assayMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1B3(Homo sapiens (Human))
Universit£Tsmedizin G£Ttingen
Curated by ChEMBL
Universit£Tsmedizin G£Ttingen
Curated by ChEMBL
Affinity DataIC50: 4.35E+4nMAssay Description:Inhibition of human OATP1B3-mediated [3H]CCK-8 after 5 mins by Dixon plot methodMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
Universit£Tsmedizin G£Ttingen
Curated by ChEMBL
Universit£Tsmedizin G£Ttingen
Curated by ChEMBL
Affinity DataIC50: 4.68E+4nMAssay Description:Inhibition of human OATP1B1-mediated [3H]estrone 3-sulfate at after 5 mins by Dixon plot methodMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of pig brain tubulin polymerization after 30 mins by turbidimetry analysisMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 0 group B member 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
TargetSteroidogenic factor 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay