BDBM50015639 CHEMBL3260567::USRE47141, Example 2
SMILES Cc1cccc(n1)-c1[nH]c(CNc2ccccc2F)nc1-c1ccc2ncnn2c1
InChI Key InChIKey=FJCDSQATIJKQKA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 29 hits for monomerid = 50015639
Affinity DataKi: 6.30nMAssay Description:Competitive inhibition of ALK5 (unknown origin) assessed as enzyme/ATP complex by Michaelis-Menten plot analysis in presence of ATPMore data for this Ligand-Target Pair
Affinity DataKi: 21nMAssay Description:Competitive inhibition of ALK5 (unknown origin) by Michaelis-Menten plot analysis in presence of ATPMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Ewha Womans University
Curated by ChEMBL
Ewha Womans University
Curated by ChEMBL
Affinity DataIC50: 97nMAssay Description:Inhibition of VEGFR2 (unknown origin) by radioisotopic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of ALK5 in human HaCaT cells assessed as inhibition of TGFbeta1-induced luciferase activity after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of ALK5 in mouse 4T1 cells assessed as inhibition of TGFbeta1-induced luciferase activity after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate incubated for 5 mins prior to substrate addition measured after 10 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate incubated for 5 mins prior to substrate addition measured after 10 mins...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate incubated for 5 mins prior to substrate addition measured after 10 m...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 5 mins prior to substrate addition measured after 10...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 5 mins prior to substrate addition measured after 10 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant ALK5 expressed in insect Sf9 cells using casein as substrate by radioisotopic assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Ewha Womans University
Curated by ChEMBL
Ewha Womans University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ALK1 (unknown origin) by radioisotopic assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ALK2 (unknown origin) by radioisotopic assayMore data for this Ligand-Target Pair
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Ewha Womans University
Curated by ChEMBL
Ewha Womans University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ALK3 (unknown origin) by radioisotopic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of ALK4 (unknown origin) by radioisotopic assayMore data for this Ligand-Target Pair
TargetBone morphogenetic protein receptor type-1B(Homo sapiens (Human))
Ewha Womans University
Curated by ChEMBL
Ewha Womans University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ALK6 (unknown origin) by radioisotopic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.72E+3nMAssay Description:Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radioisotopic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.70nMAssay Description:Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 insect cells using casein as substrate by proprietary radioisotopic protein kinase as...More data for this Ligand-Target Pair
Affinity DataIC50: 2.18E+3nMAssay Description:Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by proprietary radioisotopic protein kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.68nMAssay Description:ALK5 protein was expressed in Sf9 insect cells as human recombinant GST-fusion protein using the baculovirus expression system. Expressed protein was...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant GST-tagged ALK5 expressed in Sf9 insect cells using casein as substrate incubated for 60 mins in presence of [33P]-AT...More data for this Ligand-Target Pair
Affinity DataIC50: 2.18E+3nMAssay Description:Inhibition of human recombinant untagged p38alpha expressed in Escherichia coli using ATF2 as substrate incubated for 60 mins in presence of [33P]-AT...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of TGFBR1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant GST-tagged ALK5 expressed in Sf9 insect cells using casein as substrate incubated for 60 mins in presence of [33P]-AT...More data for this Ligand-Target Pair
Affinity DataIC50: 2.95E+3nMAssay Description:Inhibition of human recombinant untagged p38alpha expressed in Escherichia coli using ATF2 as substrate incubated for 60 mins in presence of [33P]-AT...More data for this Ligand-Target Pair
Affinity DataIC50: 2.95E+3nMAssay Description:Inhibition of recombinant human p38alpha expressed in Escherichia coli assessed as incoporation of [33]Pi after 60 mins in presence of [gamma-33P]-AT...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human GST-fused ALK5 expressed in baculovirus infected Sf9 cells assessed as incoporation of [33]Pi after 60 mins in presen...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Ewha Womans University
Curated by ChEMBL
Ewha Womans University
Curated by ChEMBL
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells after 3 to 5.7 mins by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ewha Womans University
Curated by ChEMBL
Ewha Womans University
Curated by ChEMBL
Affinity DataIC50: 54nMAssay Description:Inhibition of RIPK2 (unknown origin) by radioisotopic assayMore data for this Ligand-Target Pair