BDBM50017662 2-(Diethylamino)-2',6'-acetoxylidide::2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide::CHEMBL79::Dalcaine::LIDOCAINE::Lignocaine::N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide::Octocaine::SAMPL3, G5

SMILES CCN(CC)CC(=O)Nc1c(C)cccc1C

InChI Key InChIKey=NNJVILVZKWQKPM-UHFFFAOYSA-N

Data  21 IC50  1 ITC

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50017662   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Affinity DataIC50:  2.63E+5nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
University Of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Affinity DataIC50:  2.90E+4nMAssay Description:Modulation of human Nav1.7 in open-inactivated state assessed as inhibition of inward current after 4 mins by whole-cell electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Oryctolagus cuniculus)
Ortho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of [3H]nitrendipine binding to calcium channels in Rabbit cardiac muscle.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 18(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Affinity DataIC50: >1.00E+5nMAssay Description:Channel blocking activity at human TRESK channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily D member 2(Rattus norvegicus)
Cardiome Pharma

Curated by ChEMBL
LigandPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Affinity DataIC50:  1.21E+6nMAssay Description:Inhibition of rat potassium channel Kv4.2 by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Cardiome Pharma

Curated by ChEMBL
LigandPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Affinity DataIC50:  1.08E+5nMAssay Description:Inhibition of human heart sodium channel Nav1.5 by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Cardiome Pharma

Curated by ChEMBL
LigandPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Affinity DataIC50:  2.19E+6nMAssay Description:Inhibition of human potassium channel Kv1.5 by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Affinity DataIC50:  2.40E+5nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Affinity DataIC50:  1.80E+5nMAssay Description:Inhibition of human TREK-1 expressed in HEK293 cells by patch-clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug and toxin extrusion protein 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Affinity DataIC50:  2.63E+5nMAssay Description:Inhibition of human ERG channel in HEK293 cells by voltage-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Affinity DataIC50:  5.60E+4nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Affinity DataIC50: >1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 3(Homo sapiens (Human))
Universidad De Talca

Curated by ChEMBL
LigandPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Affinity DataIC50:  2.22E+5nMAssay Description:Inhibition of human TASK1 expressed in Xenopus oocytes by whole cell voltage clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
University Of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Affinity DataIC50:  2.00E+3nMAssay Description:Modulation of human Nav1.4 in open-inactivated state assessed as inhibition of inward current after 4 mins by whole-cell electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
University Of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Affinity DataIC50:  1.05E+4nMAssay Description:Modulation of human Nav1.3 in open-inactivated state assessed as inhibition of inward current after 4 mins by whole-cell electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Affinity DataIC50:  2.07E+5nMAssay Description:Inhibition of of human TREK1 expressed in HEK293 cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 50017662   

HostPNGBDBM197280(SAMPL3, H1)
University Of California San Diego

GuestPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
ITC DataΔG°: -6.07kcal/mole logk: 2.60E+4
pH: 7.4 T: 24.85°C 
Cell InfoPC cidPC sid