BDBM50017666 1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane::2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyridine::3-(4-bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine::3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine::3-(p-bromophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine::BROMPHENIRAMINE::CHEMBL811

SMILES CN(C)CCC(c1ccc(Br)cc1)c1ccccn1

InChI Key InChIKey=ZDIGNSYAACHWNL-UHFFFAOYSA-N

Data  4 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50017666   

TargetHistamine H1 receptor(RAT)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM50017666(1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopro...)
Affinity DataKi:  4.70nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50017666(1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopro...)
Affinity DataKi:  6.06nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM50017666(1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopro...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50017666(1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopro...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50017666(1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopro...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50017666(1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopro...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against human steroid sulfatase in fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50017666(1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopro...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50017666(1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopro...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50017666(1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopro...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50017666(1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopro...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50017666(1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopro...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50017666(1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopro...)
Affinity DataIC50:  300nMAssay Description:In vitro inhibition of accumulation of [14C]-5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM50017666(1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopro...)
Affinity DataIC50:  891nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50017666(1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopro...)
Affinity DataIC50:  4.70E+3nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]-Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed