BDBM50024605 CHEMBL3330603::US9290463, E

SMILES Cn1c(=O)cnn(CCCCN2CCN(CC2)c2ccccc2)c1=O

InChI Key InChIKey=ZIUFXZSHAGEVLS-UHFFFAOYSA-N

Data  2 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50024605   

Target5-hydroxytryptamine receptor 1A/2C(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM50024605(CHEMBL3330603 | US9290463, E)
Affinity DataKi:  0.150nM ΔG°:  -12.4kcal/molepH: 7.4 T: 2°CAssay Description:Preparation of Membrane Fractions from CHO-h5-HT1A Cells. Membranes from CHO cells stably expressing the human 5-HT1A receptor at a density of 8 pmol...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50024605(CHEMBL3330603 | US9290463, E)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1AR (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50024605(CHEMBL3330603 | US9290463, E)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed