BDBM50030196 CHEMBL3354065
SMILES CCCCC1CCN(CCCN2C(=O)CCc3ccccc23)CC1
InChI Key InChIKey=PHMGZAICAOYEAF-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 36 hits for monomerid = 50030196
Affinity DataKi: 0.977nMAssay Description:Displacement of [3H]N-methylspiperone from human D4.4 receptor expressed in HEK293T cell membrane incubated for 1 hr by MicroBeta scintillation count...More data for this Ligand-Target Pair
Affinity DataKi: 0.977nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D4 receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 7.20nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in Hartley guinea pig brain cortex after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 204nMAssay Description:Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 209nMAssay Description:Displacement of [3H]NMS from human M4 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 316nMAssay Description:Displacement of [3H]NMS from human M1 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 437nMAssay Description:Displacement of [3H]prazosin from human recombinant alpha-1A adrenergic receptor expressed in CHO cell membranes after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
Affinity DataKi: 617nMAssay Description:Displacement of [3H]N-methylspiperone from human D3R receptor expressed in HEK293T cell membrane incubated for 1 hr by MicroBeta scintillation counti...More data for this Ligand-Target Pair
Affinity DataKi: 617nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 676nMAssay Description:Displacement of [3H]N-methylspiperone from human D2L receptor expressed in HEK293T cell membrane incubated for 1 hr by MicroBeta scintillation counti...More data for this Ligand-Target Pair
Affinity DataKi: 676nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D2 receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 776nMAssay Description:Displacement of [3H]prazosin from human recombinant alpha-1B adrenergic receptor expressed in CHO cell membranes after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
Affinity DataKi: 1.00E+3nMAssay Description:Displacement of [3H]prazosin from human recombinant alpha-1D adrenergic receptor expressed in CHO cell membranes after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
Affinity DataKi: 1.20E+3nMAssay Description:Displacement of [3H]NMS from human M3 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.39E+3nMAssay Description:Displacement of [3H]WIN 35,428 from DAT in Sprague-Dawley rat striatum after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 5.37E+3nMAssay Description:Displacement of [3H]NMS from human M5 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 8.91E+3nMAssay Description:Displacement of [3H]-citalopram from SERT in Sprague-Dawley rat midbrain after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 4.37E+4nMAssay Description:Displacement of [3H]CGP12177 from human recombinant beta2 adrenergic receptor expressed in HEK293 cell membranes after 90 mins by beta counting metho...More data for this Ligand-Target Pair
Affinity DataKi: 4.79E+4nMAssay Description:Displacement of [3H]CGP12177 from human recombinant beta1 adrenergic receptor expressed in HEK293 cell membranes after 90 mins by beta counting metho...More data for this Ligand-Target Pair
Affinity DataEC50: 263nMAssay Description:Positive modulatory activity at human M1 receptor expressed in HEK293T cells assessed as effect on xanomeline-induced response by BRET based Gq prote...More data for this Ligand-Target Pair
Affinity DataEC50: 191nMAssay Description:Positive modulatory activity at human M1 receptor expressed in HEK293T cells assessed as effect on carbachol-induced response by BRET based Gq protei...More data for this Ligand-Target Pair
Affinity DataIC50: 174nMAssay Description:Antagonist activity at human M1 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced response by BRET based beta-arrestin ...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D4 receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 117nMAssay Description:Agonist activity at human SP/Myc epitope-tagged muscarinic M1 receptor expressed in HEK293T cells assessed as RLuc8-fused Galphaq activation after 2 ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.24E+3nMAssay Description:Antagonist activity at human M4 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced response by BRET based Gq protein eng...More data for this Ligand-Target Pair
Affinity DataEC50: 832nMAssay Description:Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based beta-arrestin engagement assayMore data for this Ligand-Target Pair
Affinity DataEC50: 102nMAssay Description:Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 120nMAssay Description:Positive modulatory activity at human M1 receptor expressed in HEK293T cells assessed as effect on xanomeline-induced response by BRET based Gq prote...More data for this Ligand-Target Pair
Affinity DataEC50: 35nMAssay Description:Positive modulatory activity at human M1 receptor expressed in HEK293T cells assessed as effect on carbachol-induced response by BRET based Gq protei...More data for this Ligand-Target Pair
Affinity DataEC50: 60nMAssay Description:Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein engagement assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.59E+3nMAssay Description:Antagonist activity at human M4 receptor expressed in HEK293T cells assessed as inhibition of xanomeline-induced response by beta-arrestin engagement...More data for this Ligand-Target Pair
Affinity DataIC50: 178nMAssay Description:Antagonist activity at human M4 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced response by beta-arrestin engagement ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.79E+4nMAssay Description:Antagonist activity at human M4 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced response by BRET based Gq protein act...More data for this Ligand-Target Pair
Affinity DataIC50: 1.59E+3nMAssay Description:Antagonist activity at human M1 receptor expressed in HEK293T cells assessed as inhibition of xanomeline-induced response by BRET based beta-arrestin...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+5nMAssay Description:Antagonist activity at human M4 receptor expressed in HEK293T cells assessed as inhibition of xanomeline-induced response by BRET based Gq protein en...More data for this Ligand-Target Pair
Affinity DataEC50: 275nMAssay Description:Agonist activity at human M4 receptor expressed in HEK293T cells by BRET based Gq protein activation assayMore data for this Ligand-Target Pair