BDBM50030627 (+-)-MCPG::(R,S)-alpha-Methyl-4-carboxyphenylglycine::4-(1-Amino-1-carboxy-ethyl)-benzoic acid::4-(1-Amino-1-carboxy-ethyl)-benzoic acid(S-M4CPG)::CHEMBL299683::MCPG

SMILES CC(N)(C(O)=O)c1ccc(cc1)C(O)=O

InChI Key InChIKey=DNCAZYRLRMTVSF-UHFFFAOYSA-N

Data  26 KI  9 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 35 hits for monomerid = 50030627   

TargetMetabotropic glutamate receptor 1(RAT)
Johnson And Johnson Pharmaceutical Research And Development, Beerse

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi:  165nMMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi:  334nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Johnson And Johnson Pharmaceutical Research And Development, Beerse

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(RAT)
Johnson And Johnson Pharmaceutical Research And Development, Beerse

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Novo Nordisk

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 3(RAT)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 3(RAT)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Rattus norvegicus (Rat))
University Of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Johnson And Johnson Pharmaceutical Research And Development, Beerse

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi:  5.00E+4nMAssay Description:Binding affinity towards mGluR1a was determinedMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi:  5.10E+4nMAssay Description:Antagonist potency against cloned Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi:  5.10E+4nMAssay Description:Antagonist potency against cloned Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi:  5.40E+5nMAssay Description:Agonist potency against cloned human metabotropic glutamate receptor 1More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi: >1.00E+6nMAssay Description:Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi: >2.00E+6nMAssay Description:Agonist potency against cloned metabotropic glutamate receptor 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataIC50:  1.50E+5nMAssay Description:Antagonistic activity against phospholipase C (PLC) was determined in adult rat hippocampal slicesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataIC50:  2.70E+5nMAssay Description:Inhibitory concentration required for antagonistic activity at Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataIC50:  5.00E+4nMAssay Description:Antagonistic activity against mGluR2 was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataIC50: >1.00E+6nMAssay Description:Ability to inhibit mGluR4-alpha induced cAMP formation was determined at BHK cells at 100 Micro M ConcentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataIC50:  3.40E+5nMAssay Description:Ability to inhibit mGluR2-alpha induced cAMP formation was determined at BHK cells at 100 Micro M ConcentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataIC50:  1.55E+5nMAssay Description:Ability to inhibit mGluR1-alpha-mediated PI (phospho inosotol) hydrolysis was determined at BHK cells at 100 Micro M ConcentrationMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataIC50:  2.90E+5nMAssay Description:Inhibitory concentration required for antagonistic activity at Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataIC50:  7.00E+5nMAssay Description:Compound was tested for inhibition of glutamate-evoked (10 uM) [Ca2+] mobilization in mGluR1-alpha expressed-CHO cells.More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataIC50:  1.55E+5nMAssay Description:Inhibitory concentration of the compound for half maximal inhibition of PI hydrolysis (mGluR1a)More data for this Ligand-Target Pair