BDBM50032625 CHEMBL3354187

SMILES COC1CCN(CC1)c1nccc(Nc2cc3n(C(C)C)c(cc3cn2)-c2cn[nH]c2)n1

InChI Key InChIKey=GZCREURYZWXRHS-UHFFFAOYSA-N

Data  2 KI  4 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50032625   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50032625(CHEMBL3354187)
Affinity DataKi:  16nMAssay Description:Inhibition of EGFR T790M/L858R mutant (unknown origin) by high-throughput biochemical screeningMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50032625(CHEMBL3354187)
Affinity DataKi:  367nMAssay Description:Inhibition of EGFR T790M/del746 to 750 mutant (unknown origin) by high-throughput biochemical screeningMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50032625(CHEMBL3354187)
Affinity DataIC50:  154nMAssay Description:Inhibition of Jak2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50032625(CHEMBL3354187)
Affinity DataIC50:  12nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50032625(CHEMBL3354187)
Affinity DataIC50:  107nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50032625(CHEMBL3354187)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed