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BDBM50038178 (+)-4-Amino-3-isoxazolidinone::(4R)-4-aminoisoxazolidin-3-one::(R)-4-AMINO-ISOXAZOLIDIN-3-ONE::CHEMBL771::D-CYCLOSERINE::alpha-Cycloserine::cycloserine

SMILES: N[C@@H]1CON=C1O

InChI Key: InChIKey=DYDCUQKUCUHJBH-UWTATZPHSA-N

Data: 1 KI  2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50038178   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50038178
PNG
((+)-4-Amino-3-isoxazolidinone | (4R)-4-aminoisoxaz...)
Show SMILES N[C@@H]1CON=C1O
Show InChI InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1
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n/an/an/an/a 1.81E+4n/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for in vitro inhibition of [3H]-TCP at NMDA receptor.


J Med Chem 37: 4053-67 (1995)


Article DOI: 10.1021/jm00050a001
BindingDB Entry DOI: 10.7270/Q2JM28PT
More data for this
Ligand-Target Pair
Proton-coupled amino acid transporter 1


(Homo sapiens (Human))
BDBM50038178
PNG
((+)-4-Amino-3-isoxazolidinone | (4R)-4-aminoisoxaz...)
Show SMILES N[C@@H]1CON=C1O
Show InChI InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1
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4.40E+6n/an/an/an/an/an/an/an/a



Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting


Bioorg Med Chem 19: 6409-18 (2011)

Checked by Author
Article DOI: 10.1016/j.bmc.2011.08.058
BindingDB Entry DOI: 10.7270/Q2NZ882D
More data for this
Ligand-Target Pair
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase


(Staphylococcus epidermidis (strain ATCC 35984 / RP...)
BDBM50038178
PNG
((+)-4-Amino-3-isoxazolidinone | (4R)-4-aminoisoxaz...)
Show SMILES N[C@@H]1CON=C1O
Show InChI InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1
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n/an/a 3.00E+5n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Antibacterial activity against D-alanyl-D-alanine ligase from Streptococcus faecalis (ATCC 8043)


J Med Chem 31: 1772-8 (1988)


Article DOI: 10.1021/jm00117a017
BindingDB Entry DOI: 10.7270/Q24B31XZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)
BDBM50038178
PNG
((+)-4-Amino-3-isoxazolidinone | (4R)-4-aminoisoxaz...)
Show SMILES N[C@@H]1CON=C1O
Show InChI InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1
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n/an/a 7.37E+3n/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro inhibitory activity of the compound to inhibit [3H]-glycine binding to NMDA receptor


Bioorg Med Chem Lett 9: 1409-14 (1999)


Article DOI: 10.1016/s0960-894x(99)00194-8
BindingDB Entry DOI: 10.7270/Q2W0954Z
More data for this
Ligand-Target Pair