BDBM50059190 CHEMBL3393333

SMILES FC1(F)CCN(C1)c1cc(cc(Nc2cc(ccn2)C#N)n1)C1CCN(CC1)C1COC1

InChI Key InChIKey=RHFIAUKMKYHHFA-UHFFFAOYSA-N

Data  1 KI  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50059190   

TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50059190(CHEMBL3393333)
Affinity DataKi: <0.5nMAssay Description:Inhibition of DLK (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50059190(CHEMBL3393333)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MKK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50059190(CHEMBL3393333)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MKK7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50059190(CHEMBL3393333)
Affinity DataIC50:  602nMAssay Description:Inhibition of MLK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50059190(CHEMBL3393333)
Affinity DataIC50:  514nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50059190(CHEMBL3393333)
Affinity DataIC50:  364nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50059190(CHEMBL3393333)
Affinity DataIC50:  68nMAssay Description:Inhibition of MLK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 10(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50059190(CHEMBL3393333)
Affinity DataIC50:  767nMAssay Description:Inhibition of MLK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50059190(CHEMBL3393333)
Affinity DataIC50:  30nMAssay Description:Inhibition of human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-based assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50059190(CHEMBL3393333)
Affinity DataIC50:  129nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed