BDBM50060898 5,8-Dihydroxy-[1,4]naphthoquinone::5,8-dihydroxy-1,4-dihydronaphthalene-1,4-dione (7a)::5,8-dihydroxy-1,4-naphthoquinone::CHEMBL274056::naphthazalin

SMILES Oc1ccc(O)c2C(=O)C=CC(=O)c12

InChI Key InChIKey=RQNVIKXOOKXAJQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50060898   

TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
North-West University

LigandPNGBDBM50060898(5,8-Dihydroxy-[1,4]naphthoquinone | 5,8-dihydroxy-...)
Affinity DataIC50:  3.19E+3nMAssay Description:The protocol for measuring IC50 values for the inhibition of MAO-A and MAO-B has been reported in detail in a recent publication (26). The recombinan...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase(Homo sapiens (Human))
North-West University

LigandPNGBDBM50060898(5,8-Dihydroxy-[1,4]naphthoquinone | 5,8-dihydroxy-...)
Affinity DataIC50:  860nMAssay Description:The protocol for measuring IC50 values for the inhibition of MAO-A and MAO-B has been reported in detail in a recent publication (26). The recombinan...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
WestfäLische Wilhelms-UniversitäT MüNster

Curated by ChEMBL
LigandPNGBDBM50060898(5,8-Dihydroxy-[1,4]naphthoquinone | 5,8-dihydroxy-...)
Affinity DataIC50:  3.00E+3nMAssay Description:5-LO inhibitory activity was determined by inhibition of LTB4 biosynthesis in bovine polymorphonuclear leukocytes (PMNL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens)
Lahore University Of Management Sciences

Curated by ChEMBL
LigandPNGBDBM50060898(5,8-Dihydroxy-[1,4]naphthoquinone | 5,8-dihydroxy-...)
Affinity DataIC50:  90nMAssay Description:Inhibition of Aurora A (122 to 403 residues) (unknown origin) expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in TACC3 phosphoryla...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein phosphatase 6(Rattus norvegicus)
Virginia Polytechnic Institute And State University

Curated by ChEMBL
LigandPNGBDBM50060898(5,8-Dihydroxy-[1,4]naphthoquinone | 5,8-dihydroxy-...)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of histidine-tagged rat recombinant MKP3 catalytic domain expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 1(Mus musculus)
Virginia Polytechnic Institute And State University

Curated by ChEMBL
LigandPNGBDBM50060898(5,8-Dihydroxy-[1,4]naphthoquinone | 5,8-dihydroxy-...)
Affinity DataIC50:  9.37E+3nMAssay Description:Inhibition of histidine-tagged mouse MKP1 catalytic domain expressed in human Hela cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Lahore University Of Management Sciences

Curated by ChEMBL
LigandPNGBDBM50060898(5,8-Dihydroxy-[1,4]naphthoquinone | 5,8-dihydroxy-...)
Affinity DataIC50:  350nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Virginia Polytechnic Institute And State University

Curated by ChEMBL
LigandPNGBDBM50060898(5,8-Dihydroxy-[1,4]naphthoquinone | 5,8-dihydroxy-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of histidine-tagged human recombinant Cdc25B catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed