BDBM50063908 (S)-4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazine-2-carboxylic acid tert-butylamide::CHEMBL19376

SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN[C@@H](C1)C(=O)NC(C)(C)C

InChI Key InChIKey=FACJCZHMOYUSSW-ZDUSSCGKSA-N

Data  6 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50063908   

TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50063908((S)-4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-pipe...)
Affinity DataKi:  25nMAssay Description:Compound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1B adrenergi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50063908((S)-4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-pipe...)
Affinity DataKi:  250nMAssay Description:Compound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50063908((S)-4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-pipe...)
Affinity DataKi:  510nMAssay Description:Compound was evaluated for its ability to displace [125I]-HEAT binding from rat Alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rattus norvegicus (Rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50063908((S)-4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-pipe...)
Affinity DataKi:  630nMAssay Description:Compound was evaluated for its ability to displace [125I]-HEAT binding from rat Alpha-1D adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50063908((S)-4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-pipe...)
Affinity DataKi:  830nMAssay Description:Compound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1A adrenergi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50063908((S)-4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-pipe...)
Affinity DataKi:  1.50E+3nMAssay Description:Compound was evaluated for its ability to displace [125I]-HEAT binding from rat Alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50063908((S)-4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-pipe...)
Affinity DataIC50:  1.70E+3nMAssay Description:Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the human prostate Alpha-1A adrenergic receptor subtype.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50063908((S)-4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-pipe...)
Affinity DataIC50:  31nMAssay Description:Compound was tested for the tissue binding affinity using [125I]- HEAT as radioligand to the human aorta Alpha-1B adrenergic receptor subtype.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50063908((S)-4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-pipe...)
Affinity DataIC50:  2.70E+3nMAssay Description:Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat liver Alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50063908((S)-4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-pipe...)
Affinity DataIC50:  1.50E+3nMAssay Description:Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat spleen Alpha-1B adrenergic receptor subtype.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed