BDBM50065229 4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxylic acid methyl ester::4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxylic acid methyl ester(DMCM)::4-Ethyl-6,7-dimethoxy-9H-carbazole-3-carboxylic acid methyl ester::CHEMBL17468

SMILES CCc1c([nH]cc2nc3cc(OC)c(OC)cc3c12)C(=O)OC

InChI Key InChIKey=MZTRNWROWIGTRB-UHFFFAOYSA-N

Data  34 KI  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 38 hits for monomerid = 50065229   

TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  1nMAssay Description:Binding affinity measured using LtK- cell membranes expressing Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  1nMAssay Description:Inhibition of [3H]-Ro-15-1788 binding to human GABA A receptor (alpha5-beta3-gamma2) stably expressed in L(tk-) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  1nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-5-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to human GABA A alpha5-beta3-gamma2 receptor,using a [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]-Ro- 15-1788 from human gamma-aminobutyric-acid GABA-A receptor alpha5-beta3-gamma2 expressed in L(tk-) cells More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha-5-beta-3-gamma-2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha5-beta3-gamma2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]-Ro- 15-1788 from human GABA-A alpha5-beta3-gamma2 receptor subunits expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  4nMAssay Description:Binding affinity measured using LtK- cell membranes expressing GABA alpha3-beta3-gamma2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  4nMAssay Description:Binding affinity by displacement of [3H]-Ro-15-1788 from recombinant human gamma-aminobutyric-acid A receptor alpha3,beta3,gamma2 stably expressed in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  4nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-3-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  5.70nMAssay Description:Inhibition of [3H]-Ro-15-1788 binding to human GABA A receptor (alpha1-beta3-gamma2) stably expressed in L(tk-) cells.More data for this Ligand-Target Pair
Target InfoGoogleScholar
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  5.70nMAssay Description:Binding affinity measured using LtK- cell membranes expressing GABA alpha1-beta3-gamma2 receptorMore data for this Ligand-Target Pair
Target InfoGoogleScholar
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  5.70nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-1-beta-3-gamma-2More data for this Ligand-Target Pair
Target InfoGoogleScholar
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  7.5nMAssay Description:Binding affinity to human gamma-amino butyric-acid A receptor alpha3beta3gamma2, using a [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  7.5nMAssay Description:Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha3-beta3-gamma2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  7.5nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-3-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  7.5nMAssay Description:Displacement of [3H]-Ro- 15-1788 from human gamma-aminobutyric-acid GABA-A receptor alpha3-beta3-gamma2 expressed in L(tk-) cells More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  8.30nMAssay Description:Displacement of [3H]-Ro-15-1788 from human Gamma-aminobutyric-acid A receptor alpha2-beta3-gamma2 stably expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  8.30nMAssay Description:Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  8.30nMAssay Description:Binding affinity measured using LtK- cell membranes expressing GABA alpha2-beta3-gamma2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-Ro- 15-1788 from human gamma-aminobutyric-acid GABA-A receptor alpha1-beta3-gamma2 expressed in L(tk-) cells More data for this Ligand-Target Pair
Target InfoGoogleScholar
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  10nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-1-beta-3-gamma-2More data for this Ligand-Target Pair
Target InfoGoogleScholar
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-Ro- 15-1788 from human GABA-A alpha3-beta3-gamma2 receptor subunits expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha1-beta3-gamma2 subunitsMore data for this Ligand-Target Pair
Target InfoGoogleScholar
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  10nMAssay Description:Binding affinity to human gamma-aminobutyric-acid A receptor alpha1beta3gamma2, determined using [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
Target InfoGoogleScholar
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]-Ro- 15-1788 from human GABA-A alpha2-beta3-gamma2 receptor subunits expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  13nMAssay Description:Binding affinity to human gamma-amino butyric-acid A receptor alpha2beta3gamma2, using a [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  13nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha2-beta3-gamma2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]-Ro- 15-1788 from human gamma-aminobutyric-acid GABA-A receptor alpha2-beta3-gamma2 expressed in L(tk-) cells More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]-Ro- 15-1788 from human GABA-A alpha1-beta3-gamma2 receptor subunits expressed in Xenopus oocytesMore data for this Ligand-Target Pair
Target InfoGoogleScholar
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  134nMAssay Description:Binding affinity measured using LtK- cell membranes expressing Gamma-aminobutyric-acid A receptor alpha6-beta3-gamma2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  134nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataEC50:  3nMAssay Description:Binding affinity to human alpha5beta3gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataEC50:  9nMAssay Description:Binding affinity to human alpha1beta2gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataEC50:  14nMAssay Description:Binding affinity to human alpha2beta3gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataEC50:  10nMAssay Description:Binding affinity to human alpha3beta3gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed